There is an issue in the KeyShot 10 release where if GPU and Denoise are both activated, adding an environment with pins enabled will cause the error message:

This message will not clear and optix will be disabled until KeyShot is closed and restarted. 

To avoid this issue, please add the new environment and then activate GPU and Denoise.

Our developers are working on this issue now and will have this resolved as soon as possible.  

Thank you for your patience during this time.